Dr Deng is a geneticist with extensive multi- and inter-disciplinary research experience and expertise in biostatistics and bioinformatics methodology research, genomics, transcriptomics, epigenomics, proteomics, genetic epidemiology, complex traits and diseases (especially osteoporosis), system biology, endocrinology, bone biology and recently metagenomics. Deng’s work is published in more than 500 peer-reviewed publications including journals such as Nature, New England Journal of Medicine, American Journal of Human Genetics, Endocrine Review, Plos Genetics, Human Molecular Genetics, Molecular Psychiatry, Bioinformatics, and Molecular Cell Proteomics. As of 2016, these publications have been cited more than16,000 times and his H-index is 65 and i10 index is 359. Deng’s primary research interests include all those areas that are related addressing the question: What and how genetic and environmental factors incur higher risk of, or better protection against, complex diseases, such as osteoporosis, in different sex and ethnic groups. We are most interested in generating, analyzing and integrating big data of various omics in vivo in humans. The purpose is to elucidate how DNA variants affect gene expression/regulation and protein expression/modification in the form of functional networks/modules/pathways and how the knowledge gained on these molecular mechanisms in humans would translate into better prediction/intervention/precision medicine and drug development.